Guardian debuts to lend a hand after a parasite alien drains Supergirl of her power. Mon-El considers a less than desirable new career which then leads him to contemplate his motives. Alex struggles with a new reality.
- The facility Rudy Jones works in Norway is named, Thorul Arctic Research Station. In the comics, Lex Luthor's family decided to change their surname to "Thorul" (an anagram of "Luthor") due to shame caused on them by Lex's crimes and reputation.
- During the fight with Parasite, Mon-El wears a dark blue jacket over a red shirt. This mirrors the TV show, Smallville, in which Clark Kent would frequently wear a red jacket over a blue t-shirt (or the other way around), as an homage to his classic superhero costume. This color motif on Mon-El's clothes is used for the same purpose on the show.
- At some point during the episode, Winn sits inside a truck marked "Star Spangled Delivery Co.", established in 1941. This is an easter egg to DC superhero Star-Spangled Kid, who made his debut in Action Comics #40 (September, 1941) and was created by Jerry Siegel (co-creator of Superman) and Hal Sherman.
- James and Win's describing themselves as the "Super Friends" is an allusion to the classic animated series Super Friends, a child-friendly version of the Justice League of America.
|Supergirl season 2|
|"The Adventures of Supergirl" • "The Last Children of Krypton" • "Welcome to Earth" • "Survivors" • "Crossfire" • "Changing" • "The Darkest Place" • "Medusa" • "Supergirl Lives" • "We Can Be Heroes" • "The Martian Chronicles" • "Luthors" • "Mr. & Mrs. Mxyzptlk"|
|"Homecoming" • "Exodus" • TBA • TBA • TBA • TBA • TBA • TBA • TBA|